| Date | Location | Result | |
| 03/23/21 | Columbus, OH | Drury 74, Charleston 66 | Box score |
| 03/15/21 | Columbus, OH | Charleston 82, Tiffin 52 | Box score |
| 03/13/21 | Columbus, OH | Tiffin 85, Glenville State 83 | Box score |
| 03/13/21 | Columbus, OH | Charleston 79, Walsh 73 | Box score |
| 03/07/21 | Wheeling, WV | Charleston 87, Glenville State 80 | Box score |
| 03/06/21 | Wheeling, WV | Glenville State 88, Notre Dame 69 | Box score |
| 03/06/21 | Wheeling, WV | Charleston 71, Wheeling 55 | Box score |
| 03/04/21 | Wheeling, WV | Wheeling 77, Concord 72 | Box score |
| 03/04/21 | Wheeling, WV | Notre Dame 80, W.Va. Wesleyan 33 | Box score |
| 03/04/21 | Wheeling, WV | Glenville State 118, West Liberty 87 | Box score |
| 03/04/21 | Wheeling, WV | Charleston 73, Alderson Broaddus 50 | Box score |
| 03/01/21 | Fairmont, WV | Alderson Broaddus 85, Fairmont State 79 | Box score |
| 3/1/21 | Institute, WV | W.Va. Wesleyan 100, W.Va. State 84 | Box score |
| 02/27/21 | Buckhannon, WV | W.Va. Wesleyan 75, Davis & Elkins 56 | Box score |
| 02/27/21 | Wheeling, WV | Wheeling 84, West Liberty 74 | Box score |
| 2/27/21 | Institute, WV | Charleston 92, W.Va. State 80 | Box score |
| 02/27/21 | South Euclid, OH | Notre Dame 78, Alderson Broaddus 62 | Box score |
| 02/27/21 | Fairmont, WV | Fairmont State 97, Frostburg State 53 | Box score |
| 02/27/21 | Athens, WV | Concord 97, Glenville State 86 | Box score |
| 02/25/21 | Charlotte, NC | Glenville State 112, Frostburg State 55 | Box score |
| 02/24/21 | Elkins, WV | W.Va. State 95, Davis & Elkins 70 | Box score |
| 02/24/21 | Buckhannon, WV | W.Va. Wesleyan 67, Concord 56 | Box score |
| 02/24/21 | West Liberty, W.Va. | West Liberty 94, Fairmont State 69 | Box score |
| 02/24/21 | South Euclid, OH | Notre Dame 71, Frostburg State 55 | Box score |
| 02/24/21 | Charleston, WV | Glenville State 83, Charleston 81 | Box score |
| 2/24/21 | Rex Pyles Arena | Alderson Broaddus 71, Wheeling 69 | Box score |
| 02/22/21 | Charlotte, NC | Alderson Broaddus 78, Frostburg State 42 | Box score |
| 02/13/21 | Athens, WV | Concord 74, Davis & Elkins 54 | Box score |
| 2/20/21 | Institute, WV | W.Va. State 114, W.Va. Wesleyan 69 | Box score |
| 02/20/21 | Charlotte, NC | West Liberty 90, Frostburg State 62 | Box score |
| 02/20/21 | Wheeling, WV | Notre Dame 73, Wheeling 61 | Box score |
| 02/20/21 | Athens, WV | Concord 59, Charleston 54 | Box score |
| 2/20/21 | Rex Pyles Arena | Fairmont State 106, Alderson Broaddus 93 | Box score |
| 02/19/21 | Charlotte, NC | Fairmont State 80, Frostburg State 74 | Box score |
| 02/17/21 | Wheeling, WV | Wheeling 81, Frostburg State 49 | Box score |
| 02/17/21 | Institute, WV | Concord 104, W.Va. State 93 | Box score |
| 02/17/21 | West Liberty , WV | West Liberty 84, Alderson Broaddus 74 | Box score |
| 02/17/21 | Charleston, WV | Charleston 86, Davis & Elkins 80 | Box score |
| 02/17/21 | Fairmont, WV | Fairmont State 86, Notre Dame 83 | Box score |
| 02/13/21 | Buckhannon, WV | Charleston 87, W.Va. Wesleyan 52 | Box score |
| 02/13/21 | South Euclid, OH | Notre Dame 75, West Liberty 63 | Box score |
| 02/13/21 | Fairmont, WV | Wheeling 87, Fairmont State 82 | Box score |
| 02/10/21 | Elkins, WV | W.Va. Wesleyan 68, Davis & Elkins 57 | Box score |
| 2/10/21 | Philippi, WV | Notre Dame 81, Alderson Broaddus 56 | Box score |
| 02/10/21 | West Liberty, W.Va. | West Liberty 92, Wheeling 65 | Box score |
| 02/10/21 | Charleston, WV | Charleston 86, W.Va. State 64 | Box score |
| 02/08/21 | Wheeling, WV | Charleston 82, Wheeling 53 | Box score |
| 02/07/21 | West Liberty, W.Va. | West Liberty 80, W.Va. Wesleyan 43 | Box score |
| 2/6/21 | Institute, WV | W.Va. State 99, Fairmont State 78 | Box score |
| 02/06/21 | South Euclid, OH | Notre Dame 55, Concord 53 | Box score |
| 02/06/21 | Wheeling, WV | Davis & Elkins 66, Wheeling 56 | Box score |
| 2/6/21 | Rex Pyles Arena | Glenville State 88, Alderson Broaddus 60 | Box score |
| 02/03/21 | Elkins, WV | West Liberty 77, Davis & Elkins 59 | Box score |
| 02/03/21 | Athens, WV | Concord 95, Alderson Broaddus 54 | Box score |
| 02/03/21 | Buckhannon, WV | W.Va. Wesleyan 74, Wheeling 54 | Box score |
| 2/3/21 | Waco Center - | Glenville State 76, Notre Dame 66 | Box score |
| 02/03/21 | Fairmont, WV | Charleston 99, Fairmont State 66 | Box score |
| 02/03/21 | Charlotte, NC | W.Va. State 113, Frostburg State 81 | Box score |
| 02/01/21 | Wheeling, WV | Wheeling 69, Concord 60 | Box score |
| 02/01/21 | South Euclid, OH | Notre Dame 76, W.Va. Wesleyan 66 | Box score |
| 01/30/21 | Buckhannon, WV | W.Va. Wesleyan 86, Alderson Broaddus 73 | Box score |
| 1/30/21 | Institute, WV | Wheeling 104, W.Va. State 99 | Box score |
| 01/30/21 | Charleston, WV | Charleston 87, West Liberty 71 | Box score |
| 01/30/21 | Elkins, WV | Notre Dame 90, Davis & Elkins 58 | Box score |
| 1/30/21 | Waco Center - | Glenville State 103, Fairmont State 75 | Box score |
| 01/30/21 | Athens, WV | Concord 76, Frostburg State 53 | Box score |
| 01/27/21 | West Liberty , WV | W.Va. State 83, West Liberty 61 | Box score |
| 01/27/21 | Charleston, WV | Charleston 84, Frostburg State 55 | Box score |
| 01/27/21 | Fairmont, WV | Fairmont State 90, Concord 85 | Box score |
| 1/27/21 | Rex Pyles Arena | Alderson Broaddus 84, Davis & Elkins 73 | Box score |
| 01/25/21 | Fairmont, WV | Fairmont State 100, Davis & Elkins 60 | Box score |
| 01/23/21 | Charleston, WV | Charleston 91, W.Va. Wesleyan 50 | Box score |
| 1/23/21 | Institute, WV | W.Va. State 120, Davis & Elkins 77 | Box score |
| 01/23/21 | West Liberty, W.Va. | Glenville State 101, West Liberty 98 | Box score |
| 01/23/21 | Charlotte, NC | Notre Dame 67, Frostburg State 61 | Box score |
| 01/23/21 | Fairmont, WV | Alderson Broaddus 90, Fairmont State 81 | Box score |
| 01/20/21 | Buckhannon, WV | W.Va. State 103, W.Va. Wesleyan 68 | Box score |
| 01/20/21 | South Euclid, OH | Notre Dame 74, Fairmont State 63 | Box score |
| 1/20/21 | Waco Center - | Glenville State 123, Wheeling 74 | Box score |
| 01/20/21 | Elkins, WV | Charleston 84, Davis & Elkins 55 | Box score |
| 01/20/21 | Athens, WV | Concord 68, West Liberty 56 | Box score |
| 1/20/21 | Rex Pyles Arena | Alderson Broaddus 93, Frostburg State 70 | Box score |
| 01/18/21 | Buckhannon, WV | Fairmont State 80, W.Va. Wesleyan 75 | Box score |
| 01/16/21 | Buckhannon, WV | Glenville State 98, W.Va. Wesleyan 53 | Box score |
| 01/16/21 | Wheeling, WV | Wheeling 79, Fairmont State 70 | Box score |
| 01/16/21 | West Liberty, W.Va. | West Liberty 98, Frostburg State 44 | Box score |
| 01/16/21 | South Euclid, OH | Charleston 67, Notre Dame 62 | Box score |
| 01/16/21 | Elkins, WV | Davis & Elkins 67, Concord 65 | Box score |
| 1/16/21 | Rex Pyles Arena | W.Va. State 121, Alderson Broaddus 88 | Box score |
| 01/14/21 | Fairmont, WV | West Liberty 70, Fairmont State 60 | Box score |
| 1/13/21 | Institute, WV | Notre Dame 75, W.Va. State 63 | Box score |
| 01/13/21 | Charleston, WV | Charleston 79, Alderson Broaddus 63 | Box score |
| 1/13/21 | Waco Center - | Glenville State 123, Davis & Elkins 82 | Box score |
| 01/13/21 | Charlotte, NC | Wheeling 83, Frostburg State 77 | Box score |
| 01/13/21 | Athens, WV | Concord 74, W.Va. Wesleyan 61 | Box score |
| 01/10/21 | South Euclid, OH | Notre Dame 76, Wheeling 65 | Box score |
| 01/10/21 | Charlotte, NC | Frostburg State 66, W.Va. Wesleyan 63 | Box score |
| 1/10/21 | Rex Pyles Arena | Alderson Broaddus 73, West Liberty 66 | Box score |
| 1/10/21 | Waco Center - | Charleston 91, Glenville State 86 | Box score |
| 01/10/21 | Athens, WV | Concord 70, W.Va. State 67 | Box score |
| 01/07/21 | Wheeling, WV | Wheeling 76, Alderson Broaddus 63 | Box score |
| 1/7/21 | Institute, WV | Glenville State 126, W.Va. State 82 | Box score |
| 01/07/21 | West Liberty, W.Va. | Notre Dame 83, West Liberty 71 | Box score |
| 01/07/21 | Charleston, WV | Charleston 69, Concord 56 | Box score |
| 01/07/21 | Elkins, WV | Frostburg State 73, Davis & Elkins 72 | Box score |