| Date | Location | Result | |
| Dec 10, 2016 | Shepherdstown, WV | North Alabama 23, Shepherd 13 | Box score |
| Dec 03, 2016 | California, PA | Shepherd 41, California (PA) 30 | Box score |
| Nov 26, 2016 | Brookville, N.Y. | Shepherd 40, LIU Post 21 | Box score |
| Nov 19, 2016 | Shepherdstown, W.Va. | Shepherd 48, Assumption College 31 | Box score |
| Nov 19, 2016 | Fairmont, W.Va. | Indiana (PA) 62, Fairmont State 13 | Box score |
| Nov 12, 2016 | Pembroke, N.C. | UNC Pembroke 19, Concord 18 | Box score |
| Nov 12, 2016 | Buckhannon, W. Va. | Notre Dame 26, W.Va. Wesleyan 21 | Box score |
| Nov 12, 2016 | West Liberty, W.Va. | W.Va. State 37, West Liberty 30 | Box score |
| Nov 12, 2016 | Urbana, Ohio | Shepherd 38, Urbana 14 | Box score |
| Nov 10, 2016 | Charleston, W.Va. | Charleston 17, UVa-Wise 10 | Box score |
| Nov 10, 2016 | Fairmont, W.Va. | Fairmont State 37, Glenville State 30 | Box score |
| Nov 05, 2016 | Shepherdstown, WV | Shepherd 27, Fairmont State 17 | Box score |
| Nov 05, 2016 | Philippi, WV | Alderson Broaddus 34, Charleston 17 | Box score |
| Nov 5, 2016 | Institute, WV | W.Va. State 52, Concord 45 | Box score |
| Nov 05, 2016 | Wise, Va. | W.Va. Wesleyan 35, UVa-Wise 10 | Box score |
| 11/5/16 | South Euclid, Ohio | Notre Dame 35, Urbana 14 | Box score |
| Nov 03, 2016 | Glenville, WV | West Liberty 41, Glenville State 24 | Box score |
| Oct 29, 2016 | Buckhannon, W. Va. | W.Va. Wesleyan 27, Charleston 25 | Box score |
| Oct 29, 2016 | Institute, WV | UNC Pembroke 44, W.Va. State 14 | Box score |
| Oct 29, 2016 | West Liberty, W.Va. | Shepherd 38, West Liberty 27 | Box score |
| Oct 29, 2016 | Urbana, Ohio | UVa-Wise 39, Urbana 36 | Box score |
| Oct 29, 2016 | Athens, W.Va. | Glenville State 19, Concord 8 | Box score |
| Oct 27, 2016 | Fairmont, W.Va. | Fairmont State 23, Notre Dame 19 | Box score |
| Oct 22, 2016 | Wise, Va. | Fairmont State 58, UVa-Wise 3 | Box score |
| Oct 22, 2016 | Charleston, W.Va. | Urbana 35, Charleston 34 | Box score |
| Oct 22, 2016 | Shepherdstown, WV | Shepherd 21, Concord 7 | Box score |
| 10/22/16 | South Euclid, Ohio | Notre Dame 30, West Liberty 14 | Box score |
| Oct 22, 2016 | Glenville, WV | Glenville State 43, W.Va. State 26 | Box score |
| Oct 20, 2016 | Johnson City, Tenn. | ETSU 38, W.Va. Wesleyan 7 | Box score |
| Oct 15, 2016 | West Liberty, W.Va. | UVa-Wise 28, West Liberty 27 | Box score |
| Oct 15, 2016 | Urbana, Ohio | W.Va. Wesleyan 21, Urbana 20 | Box score |
| Oct 15, 2016 | Athens, W.Va. | Notre Dame 14, Concord 10 | Box score |
| Oct 13, 2016 | Glenville, WV | Alderson Broaddus 19, Glenville State 7 | Box score |
| Oct 13, 2016 | Fairmont, W.Va. | Fairmont State 21, Charleston 13 | Box score |
| Oct 15, 2016 | Institute, WV | Shepherd 70, W.Va. State 24 | Box score |
| Oct 08, 2016 | Buckhannon, W. Va. | Fairmont State 31, W.Va. Wesleyan 17 | Box score |
| Oct 08, 2016 | Urbana, Ohio | Urbana 54, Cincinnati Christian 7 | Box score |
| Oct 08, 2016 | Charleston, W.Va. | West Liberty 40, Charleston 23 | Box score |
| Oct 08, 2016 | Shepherdstown, WV | Shepherd 38, Glenville State 7 | Box score |
| 10/8/16 | South Euclid, Ohio | Notre Dame 48, W.Va. State 21 | Box score |
| Oct 06, 2016 | Wise, Va. | UVa-Wise 30, Concord 19 | Box score |
| Oct 1, 2016 | Institute, WV | UVa-Wise 39, W.Va. State 37 | Box score |
| Oct 1, 2016 | Glenville, WV | Notre Dame 34, Glenville State 28 | Box score |
| Oct 01, 2016 | Fairmont, W.Va. | Fairmont State 48, Urbana 14 | Box score |
| Oct. 1, 2016 | Athens, W.Va. | Charleston 36, Concord 23 | Box score |
| Sep 29, 2016 | West Liberty, W.Va. | West Liberty 28, W.Va. Wesleyan 24 | Box score |
| Sep 24, 2016 | Buckhannon, W. Va. | Concord 20, W.Va. Wesleyan 17 | Box score |
| Sep 24, 2016 | Wise, Va. | UVa-Wise 26, Glenville State 17 | Box score |
| Sep 24, 2016 | Urbana, Ohio | West Liberty 21, Urbana 8 | Box score |
| 9/24/16 | South Euclid, Ohio | Shepherd 38, Notre Dame 17 | Box score |
| Sep 22, 2016 | Philippi, WV | Fairmont State 16, Alderson Broaddus 3 | Box score |
| Sep 22, 2016 | Charleston, W.Va. | Charleston 26, W.Va. State 7 | Box score |
| Sep 17, 2016 | Canton, Ohio | Notre Dame 49, Malone 21 | Box score |
| Sep 17, 2016 | Institute, WV | W.Va. Wesleyan 35, W.Va. State 14 | Box score |
| Sep 17, 2016 | Shepherdstown, WV | Shepherd 64, UVa-Wise 13 | Box score |
| Sep 17, 2016 | Glenville, WV | Glenville State 35, Charleston 28 | Box score |
| Sep 17, 2016 | Athens, W.Va. | Urbana 21, Concord 15 | Box score |
| Sep 15, 2016 | West Liberty, W.Va. | Fairmont State 21, West Liberty 20 | Box score |
| Sep 10, 2016 | Lebanon, IL | McKendree 16, West Liberty 15 | Box score |
| Sep 10, 2016 | Buckhannon, W. Va. | Glenville State 31, W.Va. Wesleyan 28 | Box score |
| Sep 10, 2016 | Wise,Va. | Notre Dame 35, UVa-Wise 29 | Box score |
| Sep 10, 2016 | Urbana, Ohio | W.Va. State 37, Urbana 24 | Box score |
| Sep 10, 2016 | Fairmont, W.Va. | Fairmont State 28, Concord 0 | Box score |
| Sep 08, 2016 | Charleston, W.Va. | Shepherd 38, Charleston 22 | Box score |
| Sep 03, 2016 | Institute, WV | Fairmont State 30, W.Va. State 20 | Box score |
| Sep 03, 2016 | Shepherdstown, WV | Shepherd 27, W.Va. Wesleyan 12 | Box score |
| 9/3/16 | South Euclid, Ohio | Notre Dame 44, Charleston 17 | Box score |
| Sep. 3, 2016 | Athens, W.Va. | Concord 32, West Liberty 25 | Box score |
| Sep 01, 2016 | Greeneville, Tenn. | UVa-Wise 13, Tusculum 10 | Box score |
| Sept 1, 2016 | Glenville, WV | Glenville State 44, Urbana 24 | Box score |